Symbiotic prodrugs (SymProDs) dual targeting of NFkappaB and CDK
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Structure-based design of novel NSAID ester prodrugs: Dual targeting of cyclooxygenase-2 (COX-2) and α7 nicotinic receptors
Non-steroidal anti-inflammatory drugs (NSAIDs) are a common treatment for chronic inflammatory disorders but suffer from several unwanted side effects, particularly in the gastrointestinal (GI) tract. The GI-related side-effects can be reduced by masking of the carboxylate moiety of the NSAID, e.g., by chemical conversion into esters. Recently, it has been shown that activation of 7 nicotinic ...
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/3-Adrenergic agonists have been used extensively and successfully in the treatment of reversible airways diseases such as asthma (Djurup, 1981). This form of therapy has proven to be particularly beneficial when the /3stimulant drug is targeted mechanically by aerosol administration directly to the defective tissue, namely the lung. Oral administration of the /3-agonist has proven less satisfa...
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ژورنال
عنوان ژورنال: Chemical Biology & Drug Design
سال: 2020
ISSN: 1747-0277,1747-0285
DOI: 10.1111/cbdd.13684